Rashford was also on the scoresheet in his previous meeting with the Hammers in Gameweek 7.
West Ham have struggled in defence and are without a clean sheet in their last eight away matches.
Brighton's centre-back boasts a big attacking threat for the two home matches in his Double Gameweek 34. Duffy has scored five goals this season, more than any other defender in FPL, ahead of visits from AFC Bournemouth and Cardiff.
The Wolverhampton Wanderers wing-back looks a standout value pick for his trip to Southampton. Costing £1.0m less than team-mate Matt Doherty (£5.3m), Jonny is owned by only 2.9 per cent of FPL managers.
Liverpool's top scorer was back on the scoresheet in last week's win at Southampton. Salah can deliver again at home to Chelsea, who travel to Anfield with only one clean sheet in their last 11 away matches.
Owned by only 7.4 per cent, the Spurs playmaker could be a major differential for the captaincy. Eriksen has two goals, two assists and 29 FPL points in his last three home outings.
The most-bought player in the Gameweek, with over 320,000 transfers in, Son has scored in both of Spurs' matches at their new stadium. Spurs host a Huddersfield Town defence who have conceded 11 goals in their last four road trips.
The Leicester City striker has flourished under Brendan Rodgers, with six goals and two assists in his last five matches. Vardy can extend his scoring streak at home to Newcastle United on Friday night.
The Brighton forward has scored seven of his 11 goals at home. Brighton host two teams this Gameweek, AFC Bournemouth and Cardiff, who have both managed only three away clean sheets in 2018/19.
Since the arrival of Ole Gunnar Solskjaer in Gameweek 18, Rashford's total of 49 shots puts him among the top three players in FPL.
Part 1: Kane owners rush to Aguero and Vardy
Part 2: GW34 Captains: Son the leading contender
Part 3: GW34 Captains: Vardy to challenge again
Part 4: FPL Show: Leave out Liverpool stars at your peril
Part 6: FPL Experts: Ryan the No 1 Double Gameweek choice
Part 7: GW34 Team news: Gross returns to managers' plans