The Wildcard chip allows managers to rebuild their squad from scratch and, with a Double Gameweek announcement pending, now is the perfect time to consider it.
Managers should look to tailor their squads to fully benefit from players with more than one fixture in a single Gameweek.
So far, over 1.5 million second Wildcards have been played. This means that more than four million are yet to be used.
Those still to activate should consider this current window, or perhaps the lead up to Gameweek 33.
This allows for preparation ahead of Gameweek 34, which is expected to be the first of the remaining Double Gameweeks.
The Wildcard becomes all the more powerful if managers also have the Bench Boost chip left to play.
This can be used to field a full squad of 15 players, all of whom have the potential to play twice in a Double Gameweek.
Only one chip can be used in a Gameweek, so those planning to use the Bench Boost in Gameweek 34 will initially need to rebuild using the Wildcard.
Kane's availability is a key consideration when using the Wildcard.
The Tottenham Hotspur striker is sidelined with an ankle injury but could return in time for Gameweek 34, when he may have two fixtures.
If Kane is to be a target for managers playing the Wildcard, they will need to build an initial squad and then use a transfer to bring in the striker.
But, managers should be aware they would have to reserve £2.1m in funds, or use an extra transfer, in order to make a subsequent swap for Kane.
Those who play the Wildcard now can plan to save their Gameweek 33 trade and take two transfers into Gameweek 34.
That may prove vital should Kane remain a doubt right up until the eve of the expected Double Gameweek.