Sergio Aguero faces Newcastle United, the opponents whom he has had the most joy against in the Premier League on Tuesday night.
Find out which competition scoring record the Manchester City striker could extend at St James' Park as well as other must-know facts for the midweek matches.
Click on the fixtures for more statistics and head-to-head records.
Huddersfield Town are looking for their first midweek Premier League victory at the ninth attempt.
Sean Dyche is looking to extend his unbeaten record in Premier League matches on Tuesdays, winning three and drawing two.
Sergio Aguero has 14 goals in 12 Premier League appearances v Newcastle, more than any player has scored against an opponent for a single club in the competition's history.
Ten of Olivier Giroud's last 13 PL goals have been as a substitute.
All three of Wilfried Zaha's PL goals this season have been scored away from home.
Spurs have scored more headed goals than any other Premier League side this season, with 12.