The midfielder opened the scoring in a 2-0 win at Sheffield United and collected the maximum three bonus points.
With 11 points he returned the highest FPL haul of any player over Saturday’s four matches.
Ward-Prowse's Southampton team-mate Fraser Forster (£4.0m) started a second successive match, with the goalkeeper helping his side to a first clean sheet since Gameweek 17.
Southampton's schedule suggests their players could prove strong value in Fantasy.
Their four opponents from Gameweek 28 onwards are all in the bottom eight of the table.
A pair of low-cost Leicester City players were also a big success on Saturday.
Daniel Amartey (£3.9m) is the top-scoring defender in Gameweek 27. He netted the winner in a 2-1 victory at Brighton & Hove Albion to pick up 10 points.
Kelechi Iheanacho (£5.6m), meanwhile, continued his improving form by scoring the equaliser at the Amex Stadium.
The forward has scored all three of his goals this season in the last six Gameweeks ahead of a favourable home match against Sheff Utd next weekend.
Aubameyang is listed as a midfielder in Fantasy but has profited from a recent move up front, producing eight goals in his last six starts in all competitions.
Aubameyang’s appeal as a premium big-hitter in Fantasy is lifted further by his upcoming matches.
He has a fine record against his next opponents, Tottenham Hotspur, producing three goals and an assist across his last two home meetings with them.
Arsenal are then among only eight sides with a fixture in Blank Gameweek 29, when they visit West Ham United.
Record in his sights 👀— Fantasy Premier League (@OfficialFPL) March 6, 2021
Emiliano Martinez (£5.3m) collected his 14th clean sheet of the season, and is now within 39 points of Brad Friedel's record points tally (187) for a goalkeeper, set back in the 2002/03 season#FPL #AVLWOL pic.twitter.com/wiKue6Rui7
He claimed his 14th clean sheet of the season to move 23 points clear of his nearest rival, Nick Pope (£5.6m).
Martinez is now the fifth highest-scoring player in Fantasy in 2020/21, thanks to a total of 149 points.
Part 1: GW27 FPL stats: Gundogan goal worth the wait for a million managers
Part 2: GW27 Bonus points: Man City trio rewarded
Part 4: FPL Sunday review: Bale and Kane become the top targets
Part 5: FPL experts: Is it time to sell Salah?
Part 6: FPL Monday review: More joy for West Ham defenders