Kane was involved in all of Tottenham Hotspur's goals in the 4-1 win, scoring twice and supplying two assists to claim 19 points.
He has now racked up 16 goals and 13 assists this season. That combined total of 29 attacking returns is his third-highest ever in his Fantasy career.
Kane has earned over 150,000 transfers in ahead of Spurs’ weekend fixture against Arsenal, second only to the 163,000+ of his team-mate Bale for Gameweek 28.
The Welshman’s two goals against Palace gave him 14 points on the night, following on the back of his 21 points in Spurs’ Double Gameweek 26.
Crucially for Fantasy managers, Bale now appears to have eased concerns over his fitness.
He has started his side’s last three Premier League matches, having previously started just two of their first 24.
Manchester United pair Bruno Fernandes (£11.5m) and Luke Shaw (£5.1m) also delivered big hauls on Sunday.
Fernandes’ early penalty and two bonus points against Manchester City gave him 10 points, his 11th double-digit return of the campaign.
Shaw combined a goal and clean sheet with the maximum three bonus to record his season-high haul of 14 points in the 2-0 derby win.
The left-back has now blanked in only two of his last 11 starts, producing one goal, four assists and six clean sheets in that period.
Fulham goalkeeper Alphonse Areola and centre-back Tosin Adarabioyo (both £4.5m) produced eight and nine points respectively in their 1-0 win at Liverpool.
Scott Parker’s side have now claimed five clean sheets from Gameweek 23 onwards, a league-leading total.
Indeed, Fulham have conceded just two goals in their last seven outings.
West Brom, meanwhile, delivered their third clean sheet in four matches in a goalless draw at home against Newcastle United.
Kyle Bartley (£4.4m) and Sam Johnstone (£4.5m) have been their top performers in that run, with 29 and 27 points respectively.
Part 1: GW27 FPL stats: Gundogan goal worth the wait for a million managers
Part 2: GW27 Bonus points: Man City trio rewarded
Part 3: FPL Saturday review: Double success for Ward-Prowse
Part 5: FPL experts: Is it time to sell Salah?
Part 6: FPL Monday review: More joy for West Ham defenders