Manchester United and Burnley are seeking to extend impressive unbeaten runs this weekend, while Wolverhampton Wanderers are looking for a long-awaited hat-trick.
Click on the fixtures for more statistics and head-to-head records.
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Spurs have won their last two PL matches despite conceding the first goal. They could now win a third successive match in that manner for the first time in the competition.
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This will be Javi Gracia's 39th PL match in charge of Watford, more than any other manager for the club in the competition.
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Only Man Utd, with seven matches, are on a longer unbeaten PL run than Burnley, who have five.
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Chelsea are aiming to avoid a third consecutive PL defeat, having last suffered a hat-trick of losses in November 2015.
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Aleksandar Mitrovic has scored 20 PL goals, with 10 coming for Newcastle United and 10 for Fulham. He has five goals apiece for four different managers: Steve McClaren, Rafael Benitez, Slavisa Jokanovic and Claudio Ranieri.
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Wolves are looking to score three or more goals in a third consecutive top-flight match for the first time since March 1980.
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Nathaniel Mendez-Laing got his first PL goal in Cardiff City's 2-1 midweek defeat by Arsenal, becoming only the second player to score in all four English league divisions since the 2014/15 season, after Alfie Mawson.
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Since the start of 2014/15, no player has more Premier League goals against Man Utd than Jamie Vardy, whose four strikes put him level with Gylfi Sigurdsson and Sergio Aguero.
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Manchester City can make it four consecutive top-flight wins over Arsenal for the first time since April 1937.
West Ham United have lost their last four PL matches against Liverpool, conceding exactly four times in each defeat.