The Arsenal midfielder has been sold by over 241,000 managers, having featured only as a substitute in their last two Premier League matches.
And there are now concerns over his fitness for Sunday's home match with Everton after he sustained an ankle problem in UEFA Europa League action.
There are also doubts over another popular mid-price midfielder.
Reaction has been quick among the Spaniard's 15.1 per cent ownership, with more than 76,000 moving him on in the last 24 hours.
Fortunately for FPL managers, there are a number of similarly priced replacements in excellent form.
Maddison's Leicester take on winless Huddersfield Town.
Richarlison (£6.6m) could also appeal as an alternative.
The Brazilian scored three goals in the first three Gameweeks and is now available for Everton after serving his three-match suspension.