The Manchester City defender is the second most-bought player in FPL, transferred in by over 1.4m managers.
Only Sadio Mane (£10.0m) with 1.48m transfers in has been more popular in the first five Gameweeks.
That interest has been due to Mendy's early-season form. The Frenchman supplied five assists and a clean sheet in his first four appearances.
But he will miss a second successive Gameweek after being ruled out of Man City's trip to Cardiff City.
Mendy's 37.5 per cent FPL owners face a dilemma if he is sidelined for a longer period.
Indeed, over 176,000 have already parted company ahead of the Gameweek 6 deadline of 11:30 BST on 22 September.
They have both replaced Mendy in 25,000+ FPL squads this Gameweek.
Marcos Alonso (£6.8m), the top-scoring defender in FPL, is another premium contender who could come in for Mendy.
Managers seeking cheaper solutions, however, could consider the Wolverhampton Wanderers defence.