Arsenal have won their last three league matches while Everton are without a victory in three fixtures.
Team news
Gunners midfielder Henrikh Mkhitaryan faces a late fitness test (knee), while Sead Kolasinac (also knee), Carl Jenkinson (ankle), Ainsley Maitland-Niles (fibula) and Laurent Koscielny (Achilles) are sidelined.
Everton welcome back Richarlison from a three-match suspension, while defender Yerry Mina (ankle), Seamus Coleman (knee) and Andre Gomes (hamstring) are closing on returns.
James McCarthy (double-leg break), Phil Jagielka (knee) and Michael Keane (face) remain out.
Did you know?
Arsenal are unbeaten in 24 home matches against Everton in all competitions (W20 D4) since a 2-1 Premier League defeat in January 1996 under Bruce Rioch.
Both of Everton's Premier League away matches this season have finished 2-2, with the Toffees leading in both matches.
Arsenal's Aaron Ramsey has scored six Premier League goals against Everton, more than he has against any other side in the competition. All six goals have come in his last four matches against them.
Forty-nine different players have scored a Premier League goal for Arsenal against Everton; the only side to have more against an opponent in the competition are Chelsea (52 v Spurs).
Referee: Jonathan Moss
Assistants: Lee Betts, Harry Lennard
Fourth official: Roger East