They went head-to-head at Anfield last weekend.
Although he converted a penalty in the 2-2 draw, Kane's earlier miss from the spot restricted him to a total of four points.
In contrast, Salah produced a brace of goals and a 15-point return to boost his captaincy credentials ahead of this weekend.
Kane has been the most popular captain pick for seven of the last eight Gameweeks.
Indeed, the Emirates Stadium defeat in Gameweek 12 is the only occasion that Kane has faced Arsenal and failed to score.
Son Heung-min (£8.1m) will also be a key figure in Saturday's early kick-off.
The South Korean midfielder has scored in seven of Spurs' last nine home matches.
And Arsene Wenger's defence have kept only three clean sheets from their 13 away fixtures.
Should Saturday's early kick-off deliver goals, Pierre-Emerick Aubameyang (£10.5m) will be backed for points.
Arsenal's signing has been signed by 159,000+ managers since scoring on his debut in last week's 5-1 win over Everton.
That makes him the most in-demand forward and the second most transferred-in player overall.
Salah is likely to mount the biggest challenge to Kane as the Gameweek's most popular captain pick.
His team-mate, Roberto Firmino (£9.2m), could also profit against a Saints defence with one clean sheet in their previous 13 at St Mary's Stadium.
The Brazilian has produced at least 10 points in three of his last five away starts.