The Chilean scored the opening goal and also completed eight dribbles, more than any other player in the Gameweek, to score 35 in the Bonus Points System (BPS).
Forming part of Arsene Wenger's three-man defence, the German recorded a score of 33 in the BPS. He made 11 clearances, blocks and interceptions (CBI) and won three tackles.
Four Arsenal players were tied on 27 in the BPS, with all receiving a single additional point.
Olivier Giroud (£8.0m) scored Arsenal's second goal from an 11-minute appearance from the bench.
Finally, goalkeeper Petr Cech (£5.3m) made three saves and nine recoveries to earn back-to-back clean sheets and bonus points over his two Gameweek 36 fixtures.
The playmaker supplied two successful crosses and provided six scoring chances in Wednesday's contest, including the assist for Sanchez's opener.
Sanchez was Arsenal's most dangerous attacker on the night, scoring 43 for Threat to rank second in the Index overall with 9.2.
He enjoyed more touches in the opposition box than any player (six) and fired two close-range shots on target.
Handed the armband by 492,000+ (11.2%) FPL managers, Sanchez was the only player in the top 10 most popular captain picks to return a double-digit score – his first since Gameweek 25.
In defence, Holding has started successive matches, keeping Gabriel (£4.8m) on the bench.
Holding has earned bonus points in both Gameweek 36 outings and FPL managers are already reacting to the value on offer, 20,000+ drafting him in ahead of Friday's 6.45pm BST deadline.
But Wenger's backline could be shuffled over the Gameweek 37 fixtures, with Laurent Koscielny (£6.1m) possibly in line for a return from injury.
Signed by 246,000+ FPL managers over the last two Gameweeks, the Italian seems likely to be retained by his owners with Saints also enjoying two fixtures over Gameweek 37.