The striker limped out of Thursday's UEFA Europa League win over Anderlecht with a knee injury, placing a major doubt over his availability for the Red Devils’ back-to-back matches at Burnley and Manchester City.
Owned by more than 30% of FPL managers, Ibrahimovic was the No 1 transfer target for Gameweek 34 prior to last night's tie, with 82,000+ acquiring his services.
But the Swede has been traded out by 46,000+ owners in the past 24 hours, with team-mate Marcus Rashford (£6.5m) emerging as the most popular replacement; more than 31,000 have swapped to the 19-year-old.
In total, over 121,000 FPL managers have acquired Rashford following a run of form that has produced three goals in his last four appearances in all competitions.
However, it is uncertain whether he will be handed successive starts over Man Utd's Double Gameweek, considering he played 120 minutes in last night’s 2-1 extra-time win.
Mourinho also has concerns in defence after Marcos Rojo (£5.2m) was forced off in the first half against Anderlecht.
Mourinho’s side head into Gameweek 34 with the best away record in the Premier League in terms of goals conceded. They have shipped only 13 goals in 14 road trips and this could promote Blind as a potential differential option for FPL managers.
Having booked a place in the semi-finals of the UEFA Europa League, Man Utd will now face a first-leg tie at Celta Vigo on 4 May, just three days before a Gameweek 36 trip to Arsenal.
The second leg at Old Trafford falls on 11 May, three days prior to the first match of their Double Gameweek 37 at Tottenham Hotspur.
While the extra fixtures will likely promote further FPL interest in Rashford, we should prepare for further rotation over the run-in as Mourinho seeks to navigate a busy schedule.