Two of the four top-scoring players in Fantasy Premier League look set to dominate the captaincy decision of managers in the reduced Gameweek 33.
Bruno Fernandes (£11.6m) is the most popular player in the game, found in 57.1 per cent of squads.
He was a huge success in his previous meeting with them, claiming 17 points thanks to two goals and an assist.
Meanwhile, Mohamed Salah's (£12.6m) backers will be optimistic he will return to the Liverpool starting line-up after appearing as a substitute in Gameweek 32.
He has a prolific record against visitors Newcastle United, scoring in three successive meetings at Anfield.
However, both Fernandes and Salah have struggled for explosive returns recently, which raises the appeal of a number of in-form alternatives.
For Man Utd, Mason Greenwood (£7.1m) has produced back-to-back double-figure hauls, while Edinson Cavani (£7.9m) has scored in three successive matches in all competitions.
Liverpool's Trent Alexander-Arnold (£7.5m) has amassed 40 points in his last four matches and team-mate Diogo Jota (£7.0m) has matched Salah's 13 shots in the box in that period.
Iheanacho has plundered 50 points and seven goals in his last five matches ahead of the Foxes' Gameweek 32 encounter with West Bromwich Albion this evening.
Vardy's average of 5.6 points per match this term ranks second among forwards.
Finally, Brighton & Hove Albion winger Leandro Trossard (£5.7m) could prove a major differential.
The Belgian, who has 30 points in his last five matches, faces a relegated Sheffield United side who have conceded 11 goals in their previous four.
Remember, the Gameweek 33 deadline is at 18:30 BST on Friday 23 April.