There is a reduced set of fixtures for Matchweek 29, but still plenty of mouthwatering action and crucial battles coming up over the weekend.
On Friday, Fulham and Leeds United kick off the action ahead of Saturday's crunch relegation showdown between Brighton & Hove Albion and Newcastle United.
London pride is at stake on Sunday in the capital derby between West Ham United and Arsenal, before Aston Villa's home match against Tottenham Hotspur brings the weekend to a close.
Here's when and how you can watch each match on TV, or by streaming through NBC Sports.
TV Info
Fulham can move outside of the relegation zone for the first time since December if they win this match.
Where to watch: Watch on NBC Sports and Peacock
TV Info
Brighton are unbeaten in all seven of their Premier League meetings with Newcastle (W3 D4).
Where to watch: Watch on Peacock
TV Info
Jesse Lingard has netted four goals in his six league appearances for West Ham, and has scored in each of his last two at home.
Where to watch: Watch on Peacock
TV Info
Spurs have won 11 of their last 12 matches against Villa in all competitions.
Where to watch: Watch on NBC Sports