Adrian Clarke looks at key tactical points in Matchweek 12.
If they do not improve their defensive structure, Man City can inflict extra misery following their local rivals' midweek exit from the UEFA Champions League.
The first half at Old Trafford will be of paramount importance for Man Utd, who have been starting matches slowly.
No Premier League side have conceded more than their 11 first-half goals, and they are facing opponents who like to begin matches at a very high tempo.
Man City have scored nine times in the opening half-hour of their matches, second only to Tottenham Hotspur's 10 in the Premier League.
I would expect the hosts to be cautious initially, just as they were in October's goalless draw at home against Chelsea.
|Man Utd||Man City|
Ole Gunnar Solskjaer’s side did the double over their neighbours last season, playing efficient counter-attacking football.
They had only 27.7 per cent of the possession in March's 2-0 home win, using a 3-4-1-2 formation.
Earlier on in the campaign, they had 28.1 per cent of the ball in a 2-1 victory at the Etihad Stadium, while using a more familiar 4-2-3-1 system.
It would be surprising if they move away from the methods that worked so well for them in those matches.
in final third
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The pair came off the bench at half-time last weekend to inspire a remarkable turnaround at West Ham, helping to turn a 1-0 deficit into a 3-1 win.
Fernandes has made more chances from open play than any other Premier League player this term, with 28.
Eight of those came in his 45-minute appearance at London Stadium.
Rashford has the pace and skill to hurt a Man City side who can leave spaces in behind their backline.
Both players are perfectly suited to the way Man Utd like to play going forward.
The key question is whether their defence will be solid enough to allow their attackers to shine.