The promise of a home fixture against the struggling Cottagers ensured Vardy was the top captain pick for the first time this season, a feat he managed on 10 occasions in 2019/20.
And although the 33-year-old could not add to his eight goals this season, it was not all bad news as Vardy did assist a late Harvey Barnes (£6.9m) consolation goal for a return of five FPL points.
GW10 most-captained players
|Captained by ('000s)
Fernandes rewarded his owners with 10 points, or 20 with the armband, after a goal and an assist at St Mary's Stadium.
There were a wide range of popular candidates in Gameweek 10, with 12 different players each being captained by over 100,000 Fantasy managers.
But they were left frustrated as the forward suffered only his second blank of the season, earning just two points.
Most-captained by top 100
Fifteen different players were chosen by the top 100 FPL managers.
Calvert-Lewin was more popular than Vardy in that elite group, while Harry Kane (£10.9m) was narrowly favoured over Fernandes.
Vardy and Fernandes also featured among the top three players transferred in for Gameweek 10. But gaining more new owners than both players combined was Diogo Jota (£6.8m).
GW10 most transferred-in players
|Transferred in by ('000s)
Making way for Jota was Wilfried Zaha (£7.3m), who was sold by more than 825,000 managers.
Defenders Romain Saiss (£5.1m) and Trent Alexander-Arnold (£7.2m) completed the top three transfers out, with the pair unavailable for selection in Gameweek 10.
GW10 most transferred-out players
|Transferred out by ('000s)