Having recovered from injury, left-back Mendy has started the last two Gameweeks and claimed a clean sheet on both occasions.
His runs forward will also trouble a Saints side who have struggled to cope with attacking left-backs this season.
Ben Chilwell (£5.6m) produced 19 points in Leicester City’s 9-0 Gameweek 10 win at St Mary's Stadium, while Marcos Alonso (£6.3m) and Diego Rico (£4.2m) have also provided attacking returns against Southampton.
The left-back produced four assists in his five home appearances last season.
The Sheffield United wing-back sits in only 1.7 per cent of squads ahead of a home match against Burnley. Stevens has been a consistent source of returns, supplying an assist or a clean sheet in six of the last nine Gameweeks.
His match against Saints can make Sterling the most-selected captain for the second Gameweek in a row. The Man City winger scored twice and supplied two assists in a 6-1 win in this fixture last term.
The Egyptian has upped his goal threat in recent matches. Salah has recorded nine shots on target over the last four Gameweeks, more than any other player in FPL.
Man City’s playmaker has been a huge success in matches at Etihad Stadium this season. Silva has two goals, three assists and 33 points in his four home starts.
Brighton’s forward has been a reliable source of goals in recent home matches, scoring in each of his last three at the Amex Stadium. Maupay can extend that run against a Norwich defence with a single clean sheet this season.
Lee Bonfield (@FPLFamily): A great mix of popular picks and differentials. Playing as Man Utd's No 9 and with some favourable fixtures, Martial should reward brave managers if he can stay fit.
Sam Bonfield (@FPLFamily): Sterling, Salah and Silva were all rested in the EFL Cup in midweek. With Mendy looking likely to play as a result of Man City's injuries, Sterling will not be having to go as wide and is therefore a fantastic captain option.
Mark McGettigan (@FPLGeneral): Great picks this week but I would have opted for John Lundstram (£4.7m) over Stevens. I'm hoping Maupay delivers for me again this week. I thought Jamie Vardy (£9.3m) would be in after his heroics last week but I do think Crystal Palace could keep him quiet.
Ben McNair (@drbenmcnair): Maupay looks a fantastic pick against a leaky Norwich defence. It’s a nice situation for his owners since Brighton’s upcoming fixtures are likely to put non-owners off buying him.
Holly Shand (@FFCommunity_): Triple Man City is a must this week. I’m excited to see if Mendy can exploit Saints down the left to the same degree that Leicester’s Chilwell did. Sterling looks set to bring in big captaincy points.
Ash (@FPLHints): The inclusion of Martial seems right. Provided he is back to full fitness, he could wreak havoc upon AFC Bournemouth's backline. I also think that Maupay could run riot against Norwich. He is a bandwagon waiting to happen.
Paul Gee (@FPLPaulGee): I love the five-man midfield selection, especially Martial. With such a low ownership, he is a strong alternative to the usual high-owned options.