There will be 35 players from 16 of the 2018/19 Premier League clubs in action at the UEFA Nations League finals as club-mates are set to face one another in the quest for European glory.
Hosts Portugal have four Wolverhampton Wanderers players in their squad, as well as Manchester City's Bernardo Silva, while their semi-final opponents Switzerland have three Premier League stars.
All but Jadon Sancho and Jack Butland of England's 23 players featured in the 2018/19 Premier League.
Some are set to line up against club-mates.
Liverpool's Dutch pair of Virgil van Dijk and Georginio Wijnaldum will be looking to stop club captain Jordan Henderson on Thursday, while AFC Bournemouth's Nathan Ake could be defending against Callum Wilson.
Portugal open the competition against Switzerland on Wednesday 5 June, with England facing the Netherlands the next day. Both matches kick off at 19:45 BST.
The semi-final winners play the final on Sunday 9 June, also at 19:45 BST, after the third and fourth-place playoff, starting at 14:00 BST.
2018/19 PL players selected
England: Tom Heaton (Burnley), Jordan Pickford (Everton); Trent Alexander-Arnold (Liverpool), Ben Chilwell (Leicester), Joe Gomez (Liverpool), Michael Keane (Everton), Harry Maguire (Leicester), Danny Rose (Spurs), John Stones (Man City), Kyle Walker (Man City); Dele Alli (Spurs), Ross Barkley (Chelsea), Fabian Delph (Man City), Eric Dier (Spurs), Jordan Henderson (Liverpool), Declan Rice (West Ham); Harry Kane (Spurs), Jesse Lingard (Man Utd), Marcus Rashford (Man Utd), Raheem Sterling (Man City), Callum Wilson (AFC Bournemouth).
Netherlands: Nathan Ake (AFC Bournemouth), Patrick van Aanholt (Crystal Palace), Virgil van Dijk (Liverpool); Davy Propper (Brighton), Georginio Wijnaldum (Liverpool), Ryan Babel (Fulham).
Portugal: Rui Patricio (Wolves); Joao Moutinho (Wolves), Ruben Neves (Wolves); Diogo Jota (Wolves), Bernardo Silva (Man City).
Switzerland: Fabian Schar (Newcastle); Xherdan Shaqiri (Liverpool), Granit Xhaka (Arsenal).