Sergio Aguero (£13.1m) heads into the weekend having scored nine goals in Gameweek 8 over the course of the previous two seasons.
The Manchester City forward scored four goals against Tottenham Hotspur in 2014/15 and followed that up with a five-goal haul against Newcastle United last term.
But Ronald Koeman's side will provide a stern test for the Argentina international, and FPL managers should also be wary of Pep Guardiola possibly choosing to handle the striker's pitch time with care.
Aguero returns from his international exertions having completed 90 minutes against Peru in the early hours of Wednesday morning. With a UEFA Champions League tie against Barcelona looming, Guardiola will be mindful of preserving his star asset.
Arsenal's Alexis Sanchez (£11.3m) and Theo Walcott (£7.7m) welcome Swansea City to Emirates Stadium and present the most viable alternatives to the Man City forward.
Played up front by Arsene Wenger, Sanchez stands at the top of the FPL midfield standings with 49 points, thanks to four goals and three assists.
Meanwhile, Walcott has already netted in home matches against Liverpool and Chelsea, producing points in five of the first seven Gameweeks.
Bob Bradley faces a tough task in his first match in charge of the visitors, only Sunderland (55 to 52) have conceded more shots inside the box than the Welsh club over the last four outings.
Having returned points in six of the first seven Gameweeks, Chelsea's Diego Costa (£10.1m) has been subject to more transfers in than any forward ahead of the Stamford Bridge encounter with Leicester City.
The Blues' striker got on the scoresheet for Spain over the break and faces a Foxes defence that has conceded 10 goals from their three road trips.
Tottenham Hotspur's Son Heung-min (£7.7m) has earned more new FPL owners than any player in the Gameweek after producing four goals and two assists in four appearances.
The EA Sports Player of the Month for September has fired 18 attempts on goal during that period and meets a West Bromwich Albion defence that has failed to keep a clean sheet since Gameweek 3.
But, with Mauricio Pochettino suggesting that he will need to assess his options ahead of seven matches in 23 days, Son is another who could have his minutes managed following international duty.
Clean sheets seem unlikely in Crystal Palace’s home encounter against West Ham United, promoting several left-field captain options.
The Eagles have yet to keep their opponents out and face a Hammers backline that has conceded more goals (17) than any other side.
Christian Benteke (£7.7m) has found the net in three of the last four league outings and scored a hat-trick for Belgium against Gibraltar earlier in the week.
Dimitri Payet (£9.4m) and Michail Antonio (£7.2m) are the main goal threats for Slaven Bilic's side.
Antonio leads all midfielders for attempts on goal (22) and efforts in the box (15) over the last four Gameweeks, yet has suffered 62,000+ sales ahead of Saturday's deadline.
Payet is the Hammers man in form. Since making his first start of the season in Gameweek 4, the mercurial Frenchman has racked up 30 points in four appearances, courtesy of a goal, four assists and six bonus points.
For all the latest Fantasy talking points, follow @OfficialFPL on Twitter. The deadline for Gameweek 8 is 11:30 BST on Saturday 15 October.