Both sides are seeking a third successive Premier League victory as they go head to head at Wembley Stadium.
Tottenham Hotspur can overtake second-placed Manchester City in Saturday's lunchtime kick-off, while Newcastle United are bidding to build on their midweek victory over Pep Guardiola's side.
Team news
Spurs will again be without left-back Ben Davies (groin), Dele Alli (hamstring) and Harry Kane (ankle).
Newcastle loan signing Antonio Barecca will be in the squad for Wembley Stadium but fellow January arrival Almiron is ineligible to play as he has yet to receive his work visa.
Mohamed Diame (groin), Karl Darlow (elbow) and Joselu (ankle) have all been training but are not ready to play.
The Spurs trip also come to soon for Rob Elliot (undisclosed) and Jonjo Shelvey (thigh) and Yoshinori Muto, who is on Asian Cup duty with Japan.
Did you know?on Asian Cup duty with Japan.
None of Spurs’ last 20 PL home fixtures against Newcastle have ended as a draw (12 wins for Spurs, eight for Newcastle).
If Tottenham Hotspur win or lose here, they would set a new PL record for the most consecutive matches without a draw (currently 28).
Spurs have won their last two PL matches despite conceding the first goal. They could now win a third successive match in that manner for the first time in the competition.
Salomon Rondon, whose six PL goals this season are twice as many as any other Newcastle player, could now score in a second successive top-flight appearance for the first time since September 2016.
Referee: Andre Marriner
Assistants: Simon Long, Sian Massey-Ellis
Fourth official: Lee Probert