The AFC Bournemouth winger has been particularly explosive in home matches this season, delivering 11, 12 and 18-point hauls at Vitality Stadium.
And that looks ominous for Brighton & Hove Albion, who make the short trip along the south coast without a clean sheet in seven Gameweeks.
The Arsenal goalkeeper could be set for a second successive home clean sheet this weekend against Burnley. Leno faces a Clarets attack who have found the net on only six occasions on their travels in 2018/19.
The centre-back has helped West Ham United earn two clean sheets in his last three Gameweek appearances. Balbuena's total of 16 shots inside the penalty area ranks fourth among defenders.
The Southampton left-back has raised his performances under new manager Ralph Hasenhuttl, creating seven chances in the last two Gameweeks. Targett visits a Huddersfield Town side who have scored only three goals at home, fewer than any other side.
Newcastle United's central defender has upped his goal threat ahead of a home encounter with Fulham. Schar has recorded six shots over his last four matches, a total bettered by only two other defenders.
The German also flourished at home to Palace last season, with one goal and two assists. Sane has three sets of double-figure hauls in his last six starts and is the most-bought player for Gameweek 18, with more than 135,000 transfers in.
West Ham's playmaker is the seventh top-scoring midfielder after a big upturn in form. Five of Anderson's six goals and two of his three assists have arrived in the last seven Gameweeks.
Fraser is this season's top-value midfielder in terms of points per million, with 14.3. He has produced four goals and seven assists for his 28.8 per cent ownership.
Arsenal's striker has big hauls of 12 and 16 points in his last five home matches. Aubameyang will hope to repeat his exploits from last season, when he produced two goals and an assist at home to Burnley.
A trip to Cardiff City can help extend his fine recent form. Rashford has produced 25 points over the last four Gameweeks, thanks to one goal and four assists.
Nick and Tom (@WGTA_FPL): Interesting to see the policy of "small at the back" used to finance a heavyweight frontline. I wonder if this is a sign of things to come for the remainder of the season.
Ash (@FPLHints): At £6.9m, I think Rashford offers exceptional value. I expect him to feature prominently under Ole Gunnar Solskjaer during the festive-fixture rush, even if he doesn't play full matches.
Ben Crabtree (@FC_CrabDogg): The 3-5-2 formation appeals to me and I like four of the five midfielders. Rashford looks a good shout and could become very popular very soon.
Lee Bonfield (@FPLFamily): No Man City or Liverpool defenders seems odd, given they're the most resilient teams in the Premier League. However, the cash has been well and truly splashed up top with a host of great picks, most of whom would be good captain candidates.
Sam Bonfield (@FPLFamily): The standout picks here are Sane and Sterling. Both have captaincy potential and are in great form going in to a home match against Palace. I also really like the Anderson pick, he has become the focal point of that West Ham attack and looks set to return points for his owners every week.
Holly Shand (@FFCommunity_): I'm jealous of the double-up on Man City attackers: a rested Sterling and Sane could have a field day at home to Palace. A rare clean sheet could be on the cards for Arsenal in their home meeting with Burnley.