The Argentinian has 14 goals against the Magpies, who visit the Etihad Stadium on Saturday, with the majority coming in his last two home fixtures against them.
For this and other must-know facts about Matchweek 4's PL fixtures, read below.
Click on the fixtures to see head-to-head records, past meetings and form guides.
Liverpool are looking to win their opening four matches of a Premier League season for the first time.
Fulham’s PL matches this season have provided the most shots (99) and the most shots on target (44). They are also the only team to have had and faced at least 20 shots on target (21 attempted, 23 faced).
Southampton have won four of their last six league matches at Selhurst Park.
Marko Arnautovic has scored first in West Ham’s last two PL matches, which were both defeats. Only three players have scored first in three successive matches without any wins: John Spencer (Chelsea, 1996), Michel Ngonge (Watford, 1999) and Steven Fletcher (Sunderland, 2012).
Four of Arsenal’s five PL goals against Cardiff City have come in the final five minutes of matches.
Spurs have never lost to Watford in the Premier League (W7 D3). Their last defeat came in May 1987, a 1-0 loss at Vicarage Road.