Tottenham Hotspur will be without Hugo Lloris after the club captain was ruled out for four weeks with a hamstring injury, though Son Heung-min is available for selection after returning from the Olympics with South Korea.
Mousa Dembele serves the fourth of a six-match suspension for the hosts.
Crystal Palace could welcome back Jordon Mutch and James McArthur, while Yohan Cabaye will be pushing for a starting place at White Hart Lane. Mile Jedinak and Yannick Bolasie were sold to Aston Villa and Everton respectively this week.
Did you know?
Four of the seven Premier League meetings between these sides at White Hart Lane have been draws (two wins for Spurs, one win for Palace).
Crystal Palace have only beaten Spurs once at White Hart Lane in the Premier League, when Neil Shipperley scored the winner in November 1997.
Harry Kane’s next Premier League goal will be his 50th. If he scores in this match then he’ll have reached this tally in 88 appearances, which will be the joint-10th quickest alongside Robbie Fowler.
Erik Lamela has had a hand in seven goals in his last seven Premier League appearances (three goals, four assists).
What the managers say
Tottenham Hotspur manager Mauricio Pochettino: "We know how they play – it will be very difficult to beat them but in the Premier League all games are very tough. It's a different season and we'll see what happens but in our minds we want to get our first victory of the season in front of our supporters."
Crystal Palace manager Alan Pardew: "Tottenham at home isn't an ideal away game for our first so we'll have to be at our best tomorrow. The way Tottenham play we have to be very good defensively, but luckily we can do that."
See: Pochettino on Palace
See: Townsend takes No 10