More than 159,000 have bought Kane ahead of his trip to Stoke City.
This follows sales of over 1.1million over the previous two Gameweeks after the striker's ankle injury against AFC Bournemouth.
Lukaku and Roberto Firmino (£9.7m) have been the forwards most affected. Over 39,000 have made the direct swap to Kane.
While Firmino’s form has faltered, with just one goal and an assist in his last four Gameweeks, Lukaku has improved his output ahead of a favourable run-in.
He has supplied four goals and two assists in his last six matches.
Manchester United are also one of only six sides who will play twice in both Gameweek 34 and Gameweek 37.
Kane has gained more than 23,000 former owners of Sergio Aguero (£11.7m).
But the popularity of Pierre-Emerick Aubameyang (£10.8m) is also on the rise.