Pep Guardiola's team have been the dominant force throughout the campaign, setting numerous records in pursuit of success.
Here we look at five key matches that defined their landmark season.
Raheem Sterling’s goal seven minutes into stoppage time earned Guardiola’s side a second Premier League win of the season as they came from behind at Vitality Stadium.
Kevin De Bruyne's stunning goal against Chelsea, his former club and the defending champions, put Man City top for the first time, above Man Utd on goal difference.
Despite the absence of Sergio Aguero, City dominated at Stamford Bridge and victory concluded a flawless month in which they won all four matches without conceding.
Guardiola called it the finest display he has seen since becoming City's head coach as his side took apart Stoke at the Etihad Stadium to move two points clear.
Fernandinho's 30-yard effort was spectacular but Leroy Sane and Gabriel Jesus also scored after brilliant De Bruyne assists as Man City scored five goals or more for the third consecutive home match.
History was made as Man City became the first team to win 14 successive PL matches in a season, equalling the record of Arsenal, who did it across two campaigns in 2002.
Nicolas Otamendi netted the decisive goal at Old Trafford to send City 11 points clear.
Aguero scored four times in the second half as Leicester City were dispatched at the Etihad Stadium. De Bruyne also starred with three assists, the first of which arrived after just two minutes and five seconds.
The win sent Man City 16 points clear, the largest lead since Man Utd in April 2013, coincidentally over City themselves.