Valencia played every minute of the season prior to limping off at West Bromwich Albion.
He is FPL’s top-scoring defender on 94 points, although more than 131,000 managers have already moved him out ahead of tonight’s 18.45 GMT deadline.
Elsewhere for United, midfielder Paul Pogba (£7.9m) will return to contention for the first time since Gameweek 15 after a three-match ban.
The playmaker missed the Gameweek 18 win over Tottenham Hotspur for personal reasons and is the most sold player in the Gameweek, with over 274,000 parting company.
If Silva remains absent, Ilkay Gundogan (£5.3m) is set to step into midfield once more and could prove a canny short-term differential.
The German is part of just 0.6% of squads, despite a goal and an assist in the 4-1 victory over Spurs.
Head coach Antonio Conte is expected to deploy a 3-4-2-1 formation in the striker's absence.
Morata was the most sold player in Gameweek 18 and sales have accelerated after his suspension, with another 266,000+ shipping out the Spaniard.
The Clarets have conceded just three goals at home this season – no side have allowed fewer – but could be without two of their first-choice back four.
The top-ranked defender for points per million (14.9), Ward has suffered over 181,000 sales.
David Moyes could hand Chicharito a role up front in a 3-4-2-1 as the Hammers prepare for a very favourable upcoming schedule.
Ten of their next 12 matches score just two in the Fixture Difficulty Rankings (FDR).