The Arsenal star has fired more shots (19) than any FPL midfielder over the last four Gameweeks and is ranked second for chances created (12).
Part of only 2.3% of squads, a big score from the Chilean could have a major impact on FPL ranks and mini-leagues.
Lukaku has been the top captain pick in eight of the first nine Gameweeks.
Kane, on the other hand, has been ruled out through injury and will not face a United side who are the only team yet to concede at home.
With defences potentially on top at Old Trafford, the field is wide open for another candidate to make their mark.
Those without Sanchez could look to Mohamed Salah (£9.1m) as an alternative.
Salah has produced double-figure returns in two of his three starts at home and is the top-ranked FPL midfielder for shots in the box (26) and shots on target (18).
Philippe Coutinho (£9.0m) is another to consider.
Since returning from injury in Gameweek 5, he is second only to Kane for shots on goal (21 to 28).
Eden Hazard (£10.6m) is another candidate and faces an AFC Bournemouth side against whom he has scored four goals in as many appearances.
Aguero and Jesus have scored seven and six goals respectively, the former Aguero netting twice in the corresponding fixture last season.
But having benched Jesus for Gameweek 9, Pep Guardiola’s rotation policy remains a concern for managers.
The 13.3%-owned Richarlison (£6.3m) is the other major differential.
Watford’s Brazilian has been brought in by 165,000+ new owners ahead of Saturday’s 11:30 BST deadline.
He has fired more shots inside the box (11) than any midfielder over the last four Gameweeks and is at home to a Stoke City side who have conceded a PL-high 20 goals.