The Liverpool winger has already suffered 270,000 sales since Saturday, almost 130,000 more than any other player.
While a big loss for Jurgen Klopp, the Liverpool manager was without Mane from Gameweek 31 last season after a knee injury.
Liverpool won five, drew two and lost one of the remaining matches.
Their goals per match fell from 2.1 to 1.8 without Mane, though they created big chances at a similar rate.
|With Mane||Without Mane|
|Goals per match||2.1||1.8|
|Mins per shot||5.8||5.3|
|Mins per big chance||47.6||47.3|
Eric Maxim Choupo-Moting's (£5.5m) brace and 15-point haul have also had a major influence on the FPL market.
The Cameroonian scored three goals in 24 Bundesliga appearances for Schalke last season, averaging a shot every 35.1 minutes.
He has scored two in four outings for Stoke, firing an attempt every 24.0 minutes, either as a central striker or, as on Saturday, from the left.
Both have attracted big investment, with Doucoure brought in by 75,000+, second only to Eriksen among FPL midfielders.
Watford's attack has already made big strides under head coach Marco Silva.
They are averaging 1.8 goals per match and have created a big chance every 64.2 minutes, up from 1.1 goals a game and 82.1 minutes per big chance in 2016/17.
Ahmed Hegazi (£4.9m) has been the most transferred-in FPL player this season; more than a million managers have brought him in.
But his withdrawal on 57 minutes in West Bromwich Albion's defeat by Brighton could be the sign of things to come.
With Gareth McAuley (£4.9m) also nearing fitness, the Egyptian faces a battle to retain his start.
That will put more than 1.4 million FPL managers on alert ahead of the Gameweek 5 meeting with West Ham United at The Hawthorns.