Palace have struggled defensively over the opening three Gameweeks, slipping to three defeats.
But Sakho will help address those frailties.
The centre-half flourished on loan at Selhurst Park in the second half of last season.
Until his debut in Gameweek 26, Palace had kept just two clean sheets, the worst record in the Premier League.
Sakho made eight starts before injury from which the Eagles earned four clean sheets.
Sakho's defensive contribution was vital, registering 66 clearances, blocks and interceptions (CBI), more than any team-mate.
Yet De Boer seems uncertain over his preferred formation, switching to a four-man defence during the Gameweek 3 defeat by Swansea City.
Having averaged 4.4 FPL points per match for Palace last season, Sakho’s influence on their defence is now eagerly anticipated.
But Palace's schedule suggests he may struggle for an immediate impact.
Those four matches score a combined 16 in the Fixture Difficulty Rankings (FDR).
So perhaps, FPL managers should revisit the Palace defence after this period.
Sakho’s bonus-point potential could make him the most profitable target, although the progress of Fosu-Mensah as a cut-price alternative should also be considered.