But with his side trailing 1-0 at the break, Klopp’s decision to introduce the duo from the bench paid off after they claimed a goal apiece to earn a 2-1 victory.
Having scored in each of the last three Gameweeks, Coutinho has been acquired by more than 60,000 FPL managers ahead of Saturday's 11.30am BST deadline.
After being limited to a cameo role in last week’s 4-0 win over Watford, Harry Kane (£11.3m) also looks set for a first-team return as Tottenham Hotspur host AFC Bournemouth.
Transferred in by 120,000+ FPL managers in the Gameweek, Kane is expected to lead the line in a 4-2-3-1 set-up, backed by attacking midfield trio Christian Eriksen (£8.8m), Dele Alli (£9.2m) and Son Heung-min (£7.1m).
Sold by 74,000+ since last weekend, the right-back had missed the last two outings before being reintroduced in the UEFA Europa League on Thursday, potentially suggesting he could be rested against Chelsea on Sunday.
United face eight fixtures in the remaining six Gameweeks but Valencia’s potential to provide full coverage for their two Double Gameweeks 34 and 37 now looks limited.
Patrick van Aanholt (£4.9m) could offer FPL managers with an alternative defensive option. He is back in contention for Crystal Palace’s home match against Leicester City.
Having recovered from an ankle complaint, the fit-again Dutchman will compete with Jeffrey Schlupp (£4.7m) for the left-back berth as Sam Allardyce’s side prepare for two Gameweek 34 fixtures against Liverpool and Tottenham Hotspur next time out.
Gabbiadini scored four times in his first three Premier League appearances before sustaining an injury in Gameweek 29, but he is back in contention as the Saints prepare for two fixtures in both Gameweeks 36 and 37.