The Leicester City talisman thrived against promoted sides last season.
Vardy totalled 42 points in his four appearances against Leeds United, West Bromwich Albion and Fulham, earning double-figure hauls on three of those occasions.
Norwich, meanwhile, have conceded a league-leading eight goals in the opening two Gameweeks.
The West Ham pair are the leading points scorers in Fantasy, on 29 and 24 respectively.
Antonio has scored three goals and supplied a further three assists, while Benrahma has two goals and two assists.
Danny Ings (£8.1m), Dominic Calvert-Lewin (£8.2m) and Patrick Bamford (£7.9m) all have strong fixtures to thrive this weekend.
Bamford, meanwhile, was involved in a team-leading 61 per cent of Leeds United’s away goals last term.
Marcelo Bielsa’s side visit Burnley, whom they beat 4-0 in the corresponding fixture of 2020/21.
The South Korean has nine double-digit returns over his last 18 home outings, including a 10-point haul against Manchester City in Gameweek 1.
And Harry Kane (£12.3m) could prove a huge differential if he starts for Spurs. Last season's top-scoring forward can be found in only 7.4 per cent of squads.
Remember, the Gameweek 3 deadline is at 11:00 BST on Saturday 28 August.