Adrian Clarke looks at key tactical points in Matchweek 20.
The 24-year-old is in scintillating form, revelling in a new role as an attacking midfielder under Jose Mourinho.
A combination of natural flair and physicality make the Frenchman one of the most unique talents in the competition.
And his ability to break the lines with a show of strength or individual skill has provided Spurs with additional potency on those all-important transitions.
With Liverpool likely to dominate possession, the home side will look for Ndombele to come alive on turnovers.
Ndombele's ability to beat a man anywhere on the field has come to the fore during a much-improved 2020/21 campaign for him.
Brilliant at getting out of tight spots, his ball-carrying will be respected by Liverpool, who will also be aware how capable he is of producing an incisive forward pass.
The Frenchman is also a lethal finisher.
Ndombele does not shoot too often. In fact, he has attempted just eight shots in the Premier League this season.
But just like last term, when he netted twice from only six attempts, Ndombele has wasted precious few opportunities.
Fresh from a quality brace against Wycombe Wanderers in the FA Cup, he will be eager to add to his tally against the champions.
If you exclude penalties, no top-flight midfielder has a better chance-conversion rate than the Spurs man since the start of this campaign.
*minimum three PL goals
When Spurs have the bulk of possession, Ndombele has little interest in dropping deep to get touches of the ball.
From those positions, he is proactive with his distribution and likes to pick out Spurs' forwards as often as possible.
Eight of the 12 chances he has created this season have been for Son (five) or Kane (three), while Pierre-Emile Hojbjerg is the only team-mate he passes to more often.
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When Spurs are defending, Ndombele becomes a very effective drop-in central midfielder.
He will get behind the ball like an orthodox central midfielder and try to retrieve possession for the side.
The France international averages 2.11 tackles per 90 minutes this season, but has made 10 across his last three starts.
Ndombele was left out of the 2-1 defeat to Liverpool at Anfield for tactical reasons, on a night when Mourinho opted to start in a 4-4-2 formation.
His performances since certainly merit inclusion in the starting XI this time round and he has the confidence and class to have a major influence.