He has produced attacking returns in six of his last seven starts, netting three goals and supplying six assists in that period.
Vardy’s potential for explosive hauls is highlighted by his five double-figure scores this season.
West Ham United also have a pair of home matches, which boost the prospects of their key players.
Cresswell has combined six assists with six clean sheets in the opening 18 Gameweeks. He sits just three points off the top of the FPL defender standings.
Soucek has stepped up his output recently, scoring in four of West Ham's last seven matches.
He has returned double-figure hauls in two of his last three outings.
Aston Villa midfielders Jack Grealish (£7.7m) and Anwar El Ghazi (£5.8m) can also take advantage of their pair of fixtures.
Grealish has created 55 chances in 2020/21, more than any other player in Fantasy.
He has combined five goals with nine assists over his 15 appearances.
FPL managers should just be aware that Grealish has accumulated four yellow cards this season, and another booking at Man City would rule him out of the home encounter with Newcastle.
El Ghazi, meanwhile, has scored all five of his goals this season in his last six matches.
Indeed, from Gameweek 12 onwards, the Dutchman’s 27 shots and 16 shots on target are both league-leading totals.
Part 1: GW19 Kings to watch: Back Pogba to maintain his form
Part 2: GW19 Differentials: Coufal an all-round prospect
Part 3: GW19 Captains: Midfielders boosted by Double Gameweek
Part 5: Who to captain in GW19? What the experts say
Part 6: Scout Selection: Soucek to reward new backers
Remember, the Gameweek 19 deadline is at 11:00 GMT on Saturday 16 January.