History and positions at the top of the table are on the line in an exciting Matchweek 27.
The top-four landscape could look much different at the end of the weekend as Saturday is bookended with four of the top five teams facing off.
Tottenham Hotspur will aim to leapfrog Chelsea into fourth place in the first match of the day, while a home win for Leicester City would move them to within a point of second-placed Manchester City.
Meanwhile, Liverpool will have the opportunity to match two historic records if they can defeat West Ham United at Anfield on Monday.
Here’s how you can watch all the action unfold this weekend.
TV Info - Broadcasters
Do you even need coffee to get you up for this match? MW27 starts off with a massive showdown with the top four on the line between Chelsea and Spurs. It's the perfect stage for Jose Mourinho to return to Stamford Bridge.
Where to watch: Stream on NBC Sports
TV Info - Broadcasters
Although Burnley host this match-up, recent history suggests that AFC Bournemouth could have the advantage as the away side. The visiting team have won four of the last five meetings in the Premier League between these two sides.
Where to watch: Stream on NBC Sports Gold
TV Info - Broadcasters
Both Crystal Palace and Newcastle United will see three points as absolutely vital when they face off in south London. Palace will be aiming to keep their first clean sheet in 10 league matches, while Newcastle will be looking for goals after being held scoreless in their last two.
Where to watch: Stream on NBC Sports Gold
TV Info - Broadcasters
For the first time, Sheffield United host Brighton & Hove Albion in a top-flight match. The fifth-placed Blades have been superb against teams in the bottom half, having won six and drawn one since losing to Newcastle in December.
Where to watch: Stream on NBC Sports
TV Info - Broadcasters
Two in-form attackers will meet in Southampton when Aston Villa travel to St Mary's. Saints' striker Danny Ings has 15 goals on the season, putting him third in the Golden Boot race, while Villa's Jack Grealish has created 68 chances, good enough for third-most in the league.
Where to watch: Stream on NBC Sports Gold
TV Info - Broadcasters
A battle at the top end of the table is in store to cap off a great Saturday when Man City visit Leicester. Jamie Vardy has proven to be up for a match against Man City in the past - the Leicester striker has been directly involved in six goals in his last seven league matches against the Citizens.
Where to watch: Stream on NBC Sports
TV Info - Broadcasters
Sunday morning, Watford will travel to Old Trafford, a stadium they've never won a league match in. Manchester United have won all six league meetings between the two, scoring 14 goals and conceding only two along the way. The match could also be the first time the Red Devils' newly-signed striker Odion Ighalo faces his former club.
Where to watch: Stream on NBC Sports
TV Info - Broadcasters
Wolverhampton Wanderers will play host to bottom-of-the-table Norwich City, who have only won a single league match on the road this season. If the Canaries can capture a lead, they will likely need to keep Wolves' star Raul Jimenez at bay if they want to keep it - seven of the Mexican's 11 goals this season have been equalizers.
Where to watch: Stream on NBC Sports
TV Info - Broadcasters
Just as Arsenal fan Rihanna celebrated her birthday this week, the Gunners will hope they have a reason to celebrate Sunday when they host Everton. The Gunners are unbeaten in their last 23 league games against the Toffees, having won 19 of those match-ups.
Birthday girl @rihanna is a Gunner 🥳 pic.twitter.com/0wjS1Hzj0l
— Premier League USA (@PLinUSA) February 20, 2020
Where to watch: Stream on NBC Sports
TV Info - Broadcasters
League-leading Liverpool are on the verge of history. The Reds have won their last 17 Premier League matches, one shy of the all-time English top-flight record set by Man City in 2017. Three points against the Hammers would also equal the English top-flight record for consecutive home wins (21).
Where to watch: Stream on NBC Sports