Vardy has failed to feature in the last two Gameweeks. But he recovered from a minor calf problem to face Aston Villa in the EFL Cup in midweek.
With a home fixture against Southampton to come on Saturday, the striker looks set to retain his status as the most-selected FPL captain.
He has been the top armband pick for nine successive Gameweeks.
The Foxes forward produced a personal season-high haul of 20 points in his last meeting with Saints, scoring a hat-trick and supplying an assist in Gameweek 10.
He has returned a goal or an assist in 10 of his last 11 appearances, with Liverpool the only side to deny him during that prolific run.
The Reds duo will look to capitalise against a Spurs defence who have kept only one clean sheet in nine Gameweeks under Jose Mourinho.
Mane, the newly-crowned African Player of the Year, has been Liverpool’s most consistent attacker in 2019/20, providing a goal or an assist in nine of his last 10 Gameweek appearances.
Meanwhile, Salah has stepped up his output recently, producing three double-figure hauls in his last five matches.
The Egyptian also has a fine record against his weekend hosts, scoring five goals in six meetings with Spurs in all competitions for Liverpool.
Both have had great success on their travels recently.
The top-scoring midfielder in FPL, De Bruyne has racked up 37 points in his last four away matches.
And Sterling has produced double-figure hauls in his last two road trips. Away from home, his 39 shots and 33 shots in the box are both league-leading figures this season.
Holly Shand (@FFCommunity_): Vardy seems the obvious pick, with a home game for Leicester against a Saints side they've already beaten 9-0 this season. Hopefully we will see that delayed baby celebration.
Paul Gee (@FPLPaulGee): It's hard to look away from the recuperated Vardy. However I would seriously look at backing a rested Mane against a Spurs team with a really poor defensive record.
Sam Bonfield (@FPLFamily): I'm torn this week. Salah versus a leaky Spurs defence looks primed for returns. De Bruyne looks good too, while I also fancy Vardy to be an excellent pick on his return for Leicester. I expect he will be the most-captained player for Gameweek 22.
FPL General (@FPLGeneral): In the last two Gameweeks without Vardy, I've had two red arrows. It will be good to have him back and he'll be my captain. I like the home fixture against Southampton. Another 9-0 victory would be nice! Marcus Rashford (£9.1m) is my vice-captain.
Ben McNair (@drbenmcnair): There are a lot of viable captains this week. Vardy will be popular, but his opponents Southampton have been in good form and he's had a minor injury. De Bruyne looks a great choice at an Aston Villa side who have conceded a league-high 23 big chances in the last six Gameweeks.
Ben Crabtree (@FC_CrabDogg): I think I'm going for Sterling. Villa are leaky and he's had a rest. There are some good home matches for other players but City can win big away.