New head coach Mikel Arteta is targeting his first victory with Arsenal at the third attempt.
Manchester United are aiming for a third successive victory as they bid to close the four-point gap to fourth-placed Chelsea.
Arsenal defender Calum Chambers is doubtful after sustaining a knee injury against Chelsea, but Granit Xhaka hopes to have recovered from illness in time to play.
Sokratis (concussion), Gabriel Martinelli (thigh), Hector Bellerin (hamstring), Rob Holding (knee) and Dani Cellabos (hamstring) will also be assessed, while Sead Kolasinac (ankle) and Kieran Tierney (shoulder) remain out.
Paul Pogba expects to be in contention for Man Utd after Ole Gunnar Solskjaer confirmed the midfielder missed the win at Burnley to get some additional rest.
Scott McTominay (knee) remains sidelined but long-term absentees Eric Bailly, Tim Fosu-Mensah and Diogo Dalot all trained on Monday and are closing in on a first-team return.
No team have won more Premier League matches on New Year’s Day than Arsenal's nine.
Pierre-Emerick Aubameyang can become the first Arsenal player to score in three successive Premier League matches against Man Utd since Thierry Henry in November 2001.
Man Utd are aiming to secure a third straight Premier League victory for the first time since they won their first six matches under Ole Gunnar Solskjaer.
Marcus Rashford has been involved in 16 goals in 20 Premier League appearances this season, with 12 strikes and four assists, but he has failed to score in his last seven top-flight appearances against Arsenal.
Referee: Chris Kavanagh. Assistants: Sian Massey-Ellis, Constantine Hatzidakis . Fourth official: Craig Pawson. VAR: Paul Tierney. Assistant VAR: Stephen Child.