Owned by 34% of Fantasy Premier League managers, Philippe Coutinho (£8.3m) could be asked to operate in a more withdrawn role should either fail to recover.
Daley Blind (£5.6m) has impressed at left-back in recent matches and may retain his start ahead of Shaw, who is the seventh-most popular defender in FPL and resides in 15.7% of squads.
De Bruyne has produced points in five of six appearances and sits joint-top of the midfield standings, averaging 8.2 points per match. Sterling is the third-most popular midfielder in FPL, residing in 24.9% of squads.
Sergio Aguero (£13.1m) allayed fears of a calf complaint by turning out for Argentina in midweek. Despite playing in the early hours of Wednesday morning, he looks in line to start up front against the Toffees.
Romelu Lukaku (£9.4m) has shrugged off a thigh complaint in time for the Etihad Stadium encounter. Everton's top scorer has produced five goals and an assist in his last four outings.
Antonio Conte opted for a 3-4-3 formation last time and faces a central defensive dilemma. Cesar Azpilicueta (£6.0m) featured as part of the back-three in Gameweek 7 but could shift to right wing-back to accommodate Terry's return.
The Blues will be without Willian (£7.2m), who has been afforded compassionate leave. Pedro (£7.1m) or Victor Moses (£5.5m) - if he recovers from a hamstring problem - could line up on the right of a front three.
Meanwhilie, Southampton's chances of a fourth successive clean sheet are dented by the news that first-choice full-backs Ryan Bertrand (£5.4m) and Cedric Soares (£5.0m) have been sidelined through injury.