Arsenal aim to win a 10th consecutive Premier League home match which could lift them above Tottenham Hotspur into third place. Newcastle, in 14th spot, are looking for a fourth win in six matches.
Gunners midfielder Lucas Torreira is suspended, although Aaron Ramsey (thigh) and Nacho Monreal (calf) returned to training and are in contention to play.
Hector Bellerin and Rob Holding (both knee) and Danny Welbeck (ankle) are unavailable.
Sean Longstaff (knee) is the only injury absentee for Newcastle, who have captain Jamaal Lascelles fit again after a knee problem of his own.
Fabian Schar has been declared fit after a clash of heads but the defender is unavailable as he serves out a two-match suspension.
Did you know?
Arsenal have won their last six home matches in the PL against Newcastle United, scoring 18 goals and conceding only five.
The Magpies have lost 11 of their last 12 PL matches against Arsenal but they did beat the Gunners as recently as last season when they won 2-1 at St James' Park.
Mesut Ozil has had a hand in four goals in as many PL matches against Newcastle, scoring three and assisting one.
Newcastle manager Rafael Benitez has taken only two points from his seven away matches against Arsenal in the PL.
Referee: Anthony Taylor
Assistants: Gary Beswick, Adam Nunn
Fourth official: David Coote