Southampton are seeking to extend a five-match unbeaten run in the Premier League.
Cardiff City are aiming for another win after beating AFC Bournemouth in their last outing, and to climb out of the bottom three.
A minute’s silence will be held before the match in tribute to Emiliano Sala.
Team News
Southampton are without striker Danny Ings, who injured his hamstring in training, but Pierre-Emile Hojbjerg has recovered from concussion.
Ryan Bertrand is also available again, as is Maya Yoshida, who is back from international duty at the Asia Cup, but Michael Obafemi (hamstring) and Mario Lemina (abdominal) are still sidelined.
Cardiff defender Sean Morrison remains out after undergoing an operation to remove his appendix.
Did you know?
Cardiff are looking to record a third consecutive victory over Southampton in all competitions for the first time since March 1963.
Southampton have both scored (11) and conceded (12) in each of their last seven PL home matches.
Cardiff have the chance to secure a second consecutive top-flight victory for the first time since April 1962.
The Bluebirds' last five PL away goals have come in the 80th minute or later, with three of them coming in the 90th minute.
Referee: Martin Atkinson
Assistants: Stephen Child, Harry Lennard
Fourth official: Tim Robinson