Mohamed Salah (£13.0m) will have competition as the go-to captain choice for Fantasy Premier League managers in Gameweek 2.
The Liverpool winger was the top pick for the Gameweek 1 armband, backed by 34.6 per cent of managers.
He scored Liverpool's opener in the 4-0 home win over West Ham United to return eight points.
The Egyptian produced 13 of his 32 goals away from home in 2017/18, scoring every 105 minutes.
He faces a defence who claimed only four clean sheets at Selhurst Park last term.
And, with an ownership of over 54 per cent, he will again be among the big captaincy favourites.
Aguero was more prolific at home last season. He averaged a goal every 79.3 minutes and 15 of his 21 strikes came at the Etihad Stadium.
He is set to face a Huddersfield side who struggled defensively on the road in 2017/18, managing only three clean sheets away from home.
Similar issues surround Fulham. They conceded 10 shots on target in Gameweek 1, more than any other side.
Just like Aguero, Kane scored 15 goals at home last season.
And his totals of 111 shots and 49 shots on target at home were more than any other player.
The captaincy decision can make or break a Gameweek.
Whether to twist on Aguero or Kane, or stick with the more popular Salah, looks like being trickier than most.
Nick (@WGTA_FPL): I'm backing Salah. Both Kane and Kun [Aguero] didn't seem on form in Gameweek 1 and, despite the great fixture, Kun may have reduced minutes due to Jesus waiting in the wings. It could be argued Salah has a higher points ceiling, too, due to being classified as a midfielder.
Ash (@FPLHints): With a goal in his last match and over 50 per cent ownership, Salah is my pick. But if you are already chasing points, Aguero would be a good alternative.
Mark McGettigan (@FPLGeneral): The closer the weekend gets, the closer I'm getting to switching from Salah to Aguero. Come Saturday, I'll get the "Pep fear" and stick with Mo.
Ben Crabtree: I like the idea of Kane but only own Kun. The risk of him not starting is smaller than the potential for a big points haul if he does.
Simon March (@MarchSimon): Salah might be the "safe" choice but, if you can't take a "risk" on Aguero at home to Huddersfield at the start of the season, when can you?