Paul Pogba is in line to make his Manchester United debut after serving a suspension in Sunday’s defeat of AFC Bournemouth.
Chris Smalling is also available to manager Jose Mourinho after a ban while Jesse Lingard could return after missing out through injury at Vitality Stadium.
Southampton remain without the injured Ryan Bertrand but otherwise boast a clean bill of health, with captain Jose Fonte in contention having trained all week.
Did you know?
Southampton are unbeaten in their last three away Premier League matches against Manchester United (W2 D1). United had won 13 of 14 previous fixtures.
The Saints have won their last two league trips to Old Trafford. They have never won three in a row there in their entire league history.
Jose Mourinho has lost four of his last seven home league matches as a manager, the same number he’d lost in his previous 232 league matches on home soil (W190 D38 L4).
After scoring on MD1 versus Watford, Southampton’s Nathan Redmond could score in the opening two matchdays for the second Premier League season in a row.
What the managers say
Man Utd manager Jose Mourinho: "Everything starts there: the relationship between the team and the fans. If there is a connection then the factor of being really strong at home has to be back. The way we play [will help] and if the fans play [a part] there'll be no chance for the opponent."
Southampton manager Claude Puel: "We have prepared with good training sessions for this game. It is just the second game of the season and it will be interesting to see my team against a very good team with great players and I think we can make a good game and perhaps take one or three points.”
