The summer signing has started only six PL matches this season, earning another 16 appearances from the bench.
But he looks set to be handed an opportunity in light of Leroy Sane's (£8.4m) ankle injury.
The German winger could be out for six to seven weeks.
Owned by only 0.7% of FPL managers, Silva has supplied three goals and six assists in his last 13 matches across all competitions ahead of a home encounter with West Bromwich Albion.
Meanwhile, Willian (£6.8m), one of the Gameweek's hottest properties, will sit out the midweek round.
Alternatively, Michy Batshuayi (£8.1m) could lead the attack in a rare Premier League start.
The Armenian started the season with a bang with Manchester United, supplying a goal and five assists over the first five Gameweeks to rise in price to £8.5m.
Now part of only 7.1% of squads, a kind schedule could bring him back into contention in Fantasy with eight of Arsenal's next 11 matches scoring only two in the Fixture Difficulty Rankings (FDR).
Handed a role on the left against Yeovil Town in the FA Cup, the Chilean impressed by providing two assists in the 4-0 win.
But Anthony Martial (£8.0m) has recently occupied that position for Jose Mourinho's side, scoring in each of the last three Gameweeks.
The centre-half is in contention for the first time since limping off with a calf problem in Gameweek 16.
Before that fixture, Sakho had scored 28 points in three appearances over Gameweeks 13-15, supplying a goal, two clean sheets and eight bonus points.