Even though he is the most-owned and the highest-scoring player in FPL, Salah was last the top captaincy pick in Gameweek 21.
The Egyptian is capable of a repeat performance at Huddersfield Town as he looks to return to the consistent form that has delivered a goal or assist in 12 of his last 14 Gameweek appearances.
However, he has mixed memories of the Terriers.
He got an assist in a 3-0 win against them in Gameweek 10, but also saw his penalty saved by Jonas Lossl (£4.6m).
Now owned by 26.7% of managers, Aguero will run Salah close.
He goes into a home fixture with West Brom as the most-bought player ahead of Tuesday's 18:45 GMT deadline.
Over 179,000 managers have signed him after a run of eight goals in seven appearances across all competitions in January.
Kane is in danger of being overlooked after being the most popular choice in five of the previous six Gameweeks.
Kane has scored only once in six Premier League starts against United, although that goal came in last season's corresponding fixture at White Hart Lane.
Also, despite keeping four successive clean sheets, United have conceded 36 shots in the penalty area over those four Gameweeks. No side have allowed more.
That could also benefit Kane's team-mate Son Heung-min (£8.2m).
The South Korean has been prolific at Wembley Stadium, scoring in seven of the last eight home matches.
Eden Hazard (£10.6m) is another contender managers should consider.
He has found the net in each of his last four Premier League meetings against the Cherries, producing five goals.
Also among the Chelsea team, FPL managers should not overlook Marcos Alonso (£7.3m) as a differential for the captaincy.
The top-scoring defender in FPL has supplied 42 points in his last four Stamford Bridge appearances.
Alonso has scored at least six points in his previous eight Gameweek outings and is in good form, providing a goal and an assist in Sunday’s FA Cup win over Newcastle United at the Bridge.