Southampton's only absentee will be right-back Cedric Soares (hamstring).
Arsenal are without defender Shkodran Mustafi, but Theo Walcott is fit despite a calf strain in midweek.
Did you know?
Southampton have only lost one of their last six home Premier League matches against Arsenal, although that defeat was in the last such meeting back in May.
Arsenal haven't won successive away league fixtures at Southampton since August 1997.
Fraser Forster has conceded five goals in his five PL matches against Arsenal, despite the Gunners having 30 shots on target against the goalkeeper.
Alexis Sanchez (9) and Ian Wright (10) are the only two Arsenal players to have scored more goals in their first 15 Premier League appearances for the club than Alexandre Lacazette (8).
What the managers say
Mauricio Pellegrino: "They’ve bought important players and they are a really difficult team to beat. They are a top team."
See: Soares Southampton player of the month
Arsene Wenger: "There should be goals because they (Southampton) are an offensive team as well, with offensive potential."
See: Wenger: There should be goals in Saints match
Referee: Bobby Madley
Assistants: Stephen Child, Marc Perry
Fourth official: Graham Scott
