Stoke City defender Bruno Martins Indi could be out for up to eight weeks after suffering a groin injury against Swansea City.
Geoff Cameron (concussion) is available again but Jese Rodriguez will not travel to London because of personal reasons.
Tottenham Hotspur will be without the suspended Davinson Sanchez, while Toby Alderweireld (hamstring) and Victor Wanyama (knee) are injured.
Tottenham Hotspur have won each of their last three Premier League matches against Stoke City all by a 4-0 scoreline, no side in top-flight history has won four consecutive matches by four or more goals.
Stoke's Xherdan Shaqiri has been directly involved in nine goals in his last 11 PL appearances (four goals, five assists).
The Potters have won four of their five visits to Wembley Stadium in all competitions.
Tottenham Hotspur have lost only one of their last seven home matches against Stoke City.
Mauricio Pochettino: "In general, I am positive, I am optimistic. I think we need to improve in different areas but I think we are focused now only on Premier League."
Mark Hughes: "Whenever we went up against them we always thought it was the toughest game for us - for whatever reason they always cause us problems. We will be looking to address that."
Referee: Roger East
Assistants: Adrian Holmes, Mick McDonough
Fourth official: Paul Tierney