The Egyptian was handed only 23 minutes off the bench at Stoke City on Wednesday night, yet still scored a brace to tally 13 points.
He has netted twice in three of the last four Gameweeks to soar away at the top of the overall standings on 108 points.
Salah provides the main challenge to Kane this time around.
Seven of Kane's 10 league goals have arrived on his travels, producing three 13-point tallies.
Away from home, he has fired more shots (33), shots inside the penalty area (22) and shots on target (12) than any other player.
Faith in Lukaku is in decline after only a single goal in his last seven Gameweeks.
The Belgian's struggles could continue at Emirates Stadium: the Gunners have conceded only one goal in their last six matches.
Alexis Sanchez (£11.8m) will take on the Red Devils in fine form.
He has netted four goals in the last six Gameweeks, while over the same period, Man Utd's defence has claimed only two clean sheets.
Afforded only nine minutes from the bench against Swansea City in midweek, Hazard has three goals and two assists in his last four starts.
Meanwhile, Morata failed to find the net against Paul Clement's side, yet fired six shots and four shots on target - no player produced more in Gameweek 14.
The Magpies arrive at Stamford Bridge with one clean sheet from their previous 10 Gameweeks.
Manchester City's attackers also demand consideration.
With concerns over rotation up front, and with Leroy Sane (£9.0m) a doubt following a virus, Sterling is perhaps the favoured option.
He has averaged 9.6 points per match (ppm) on home turf.
The FPL midfielder will test a Hammers defence that has conceded more goals (19) away from home than any other side.
A pair of proven goal scorers provide the differential options.
Huddersfield Town are Saturday's visitors to Goodison Park for Sam Allardyce's first match in charge. The Terriers have conceded 12 goals in their last three away matches.
Finally, Jamie Vardy (£8.5m) heads into Saturday's 11:30 GMT deadline as the most sought-after forward.