Tammy Abraham (£6.0m) is the No 1 FPL forward for points-per-million value at 8.3 and has earned 341,000+ transfers in over the last two Gameweeks.
But Swansea's top scorer with four goals is rated "50-50" by head coach Paul Clement after going off in Gameweek 12 with a back injury.
His 15% owners have a dilemma, because Abraham cannot play against his parent club, Chelsea, in Gameweek 14, next Wednesday evening.
Clement could hand Wilfried Bony (£5.7m) his first start since Gameweek 7 should Abraham fail to recover.
The forward was bought by 147,000+ FPL managers this Gameweek before his ban, having returned 19 points across his previous two appearances.
But with five goals and an assist in his seven outings, Niasse could still be an option when he returns for Gameweek 15.
From that point, five of his next seven matches score only two in the Fixture Difficulty Rankings (FDR).
Sales of Jones have escalated ahead of a busy schedule of fixtures.
He was transferred out by more than 159,000 managers after missing last week’s win over Newcastle United and is the second-most sold defender in the Gameweek, with a further 135,000 losses.
Jose Mourinho has also revealed he will continue to manage the pitch time of Paul Pogba (£8.0m) after the Frenchman returned from injury in Gameweek 12, with 69 minutes against Newcastle, during which time he produced a goal and an assist.
Pogba is the most-bought player for Gameweek 13, with 333,000+ new owners.
Zlatan Ibrahimovic (£10.0m) will continue to earn minutes off the bench as he steps up his own return from injury.
The Swede offers an option in the No 10 role or up front if Mourinho looks to rest Romelu Lukaku (£11.5m), who has played every minute of the season.
Otamendi was the most-sold player (358,000) in the previous Gameweek and is likely to be joined in the back four by fit-again captain Vincent Kompany (£5.8m).
Before missing out against Leicester City last weekend, Otamendi had more FPL points (56) than any defensive team-mate, and had topped the overall defender standings.