Manchester United could welcome back defenders Eric Bailly (groin) and Phil Jones (knock).
Marouane Fellaini (knee), Michael Carrick (calf), Zlatan Ibrahimovic (knee), and Paul Pogba (hamstring) are all sidelined.
Tottenham Hotspur striker Harry Kane (hamstring) has been ruled out, as has midfielder Victor Wanyama.
Did you know?
Manchester United have won 20 of their past 25 Premier League home matches against Tottenham Hotspur (D3 L2).
Spurs, who beat Man Utd in May, can record consecutive PL victories against the Red Devils for the first time.
Mauricio Pochettino has lost more PL matches against Jose Mourinho (4) than he has versus any other manager in the competition.
Fifteen of Harry Kane’s 29 PL goals in 2017 have come away from home – only Sergio Aguero (17 in 2016) and Robin van Persie (19 in 2011) have scored more on the road in a single calendar year.
What the managers say
Jose Mourinho: "At home we are a strong and confident team, so we will try to do the same tomorrow."
Mauricio Pochettino: “It’s not an excuse that there is no Harry Kane tomorrow. We have Fernando, Son, we have options. We’ll take the best decision for the team.”
See: Pochettino on Kane injury
Referee: Jonathan Moss
Assistants: Simon Bennett, Andy Halliday
Fourth official: Stuart Attwell