But the Argentinian has made an early recovery and could now feature against the Potters.
Fellow striker Gabriel Jesus (£10.6m) has claimed 349,900+ new owners in anticipation that he will earn a start on Saturday.
They will hope that Pep Guardiola is cautious with Aguero’s minutes with a UEFA Champions League match against Napoli to come next week.
But concerns of rotation in the Man City attack will now be renewed.
While Aguero is back, Alvaro Morata (£10.3m) remains off the FPL radar.
Morata has been sold by 512,000+ managers over the international break following a hamstring injury.
But his absence is expected to be short term and Antonio Conte is hopeful the striker can return in the UEFA Champions League encounter versus Roma.
From Gameweek 9 onwards, eight of Chelsea’s following 10 matches score only two in the Fixture Difficulty Rankings (FDR).
Chelsea's defence could be up against Wilfried Zaha (£6.7m) on Saturday.
The winger may feature for the first time since Gameweek 1 as the Eagles bid to score their first goal of the campaign.
Zaha is the third most sold midfielder this season, with 955,000+ moving him out.
But manager Roy Hodgson may now look to the winger to lead his attack in the continued absence of Christian Benteke (£7.6m).
The Brazilian has been sold by 195,000+ managers over the break.
His stock suffered a further blow with Klopp stating that Mohamed Salah (£9.2m) is set to replace Firmino as his first-choice penalty taker.
Philippe Coutinho (£9.0m) could shift to the left of Liverpool's attacking three after his recent return in midfield.
Coutinho has been acquired by more than 131,000 new owners in the Gameweek, having supplied 23 points over his last two appearances.
But the Gunners' bid for a fifth successive clean sheet could be thwarted by concerns in defence.
Their availability will likely decide whether Rob Holding (£4.7m) can stand out as a cut-price option over the Gameweeks to come.