Huddersfield Town will be without Jonathan Hogg and Nahki Wells (both ankle) and defender Martin Craine (hip).
Southampton have a fully-fit squad and could give a debut to new signing Wesley Hoedt.
Did you know?
Huddersfield Town have started the season with two wins. Bolton Wanderers were the last newly-promoted side to win their first three PL matches in 2001/02.
Huddersfield have also kept two clean sheets this season. Charlton Athletic were the last newly-promoted side to keep three in 1998/99.
Since the start of 2014/15, Fraser Forster has kept 34 clean sheets in 88 PL matches, more than Chelsea's Thibaut Courtois (33 in 93 matches).
Southampton have won more PL away matches in 2017 (four of 10) then they have at home (three of 11).
What the managers say
David Wagner: "We have to make the John Smith's Stadium a tough place for opponents to come. We will try to do that and I know the fans will too."
See: Wagner: At our best
Mauricio Pellegrino: "Huddersfield won the last two games and we know it will be really difficult in this pitch. They are an intelligent team with the ball and without the ball."